What are dropper bottles used for?

Dropper bottles are often used for storing eye-drops. These dropper bottles have a tight fitting cap which acts just like a dropper. However, this dropper can either be marked or not. Their main function is the dispensing of a small quantity of liquid which is just perfect for eye application.

eye dropper bottles

These dropper bottles are produced through injection blow moulding and sealed in PE bags under cleanroom conditions, ISO class 8. Sterile Eye Dropper Bottles, Nozzles and Caps are also available as are bottles and caps in other colours (for viable production runs).

We are one of the leading manufacturers of eye dropper bottles for pharmaceutical companies. eye dropper vials, generally used to transfer small quantities of liquids. Our eyedroppers are completely adaptable to your requirements, with a large range of sizes, capacities and designs as well as tamper evident features.

How to test blood sugar

The test way of blood sugar as following:

1.Before you begin, gather all the necessary materials: a blood glucose meter; test strips, alcohol swabs, and lancets. Make sure that the meter is installed with a working battery on a flat surface.

2.If the test strip is packaged separately, open the test strip container  or remove the test strip from the aluminum foil. Insert a new strip into the device.

3.Make sure the calibration code on the test strip is the same as shown on the meter

blood sugar test kit

4.Wash your hands or clean your fingers with an alcohol swab. If you are using alcohol, dry your fingers before puncturing them.

5.Use a new lancet to stab one side of your fingertips to reduce pain.

6.Turn on the blood glucose meter (some models of test strips start automatically as soon as they are inserted). Confirm that the test code number shown on the display is the same as the code on the current test strip package.

7.Drop a few drops of blood on the test strip (refer to the blood glucose meter manual provided for the required blood volume)

8.The meter reads your blood sugar level in seconds.

9.Record your blood glucose readings in a notebook for your own reference and that of your doctor. Some meters have large memory to store blood glucose readings.

How to do diabetes home test kit

A home blood sugar test kit reads glucose testing strips. These strips allow the machine to detect the level of glucose in a drop of blood.

People obtain a sample of their blood with a lancet, or small, short needle.

For the most accurate testing, people should keep a record or log of the food they eat and look for trends in their blood glucose readings.

glucose test strip container

Whether consuming a high- or low-carbohydrate meal, a higher-than-normal blood sugar reading after a person has eaten suggests that their body is not reducing blood glucose successfully after mealtimes.

Before testing, people will need to read the manual for the blood glucose monitor and testing strips. Many home glucose monitors work in different ways. In most cases, people should only insert testing strips into the monitor immediately before a reading.

After consulting a doctor about the right testing schedule and frequency, a person can follow these steps:

Wash and dry the hands before handling the testing kit.

Some methods recommend cleansing the testing area with an alcohol swab. Others may merely advise washing with warm, soapy water. With either, make sure the area is dry before taking a sample.

Some glucose monitors allow testing on the arm or another, less sensitive area of the body. Rapid changes in blood sugar may not present accurately in less sensitive areas. The finger is usually best when monitoring for rapid changes in blood sugar.

When testing on the finger, use the side of the finger, and test different fingers on each occasion. Most lancets allow the user to set how deep they penetrate the skin. People with thicker or drier skin should set the penetration higher.

Before lancing the finger, position it against a solid surface. Apply the lance firmly but not forcefully.

Gently squeeze the finger while holding it at chest level and allow a drop of blood to flow onto the diabetes home test kit.

Note and record the blood glucose reading following each test.

Blood testing near our life

Blood has always held the keys to our bodies’ health: it helps carry nutrients in and waste out, and interrogating it can provide solace when we are well and answers when we are sick.

glucose test strip container

Blood testing is ubiquitous, but it’s clear its possibilities are unfulfilled. Through different methods and modalities, these diagnostics promise to be a more accessible, less invasive, smarter, cheaper and a comprehensive way to gather knowledge about what’s going on under the skin-whether in a doctor’s office, at home or within a clinical laboratory.

Merry Christmas

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How to reduce cost by plastic syringe

As a special package, the plastic syringe is not a medical device, but a drug packaging system. The plastic syringe has both the packaging drug and the syringe.

dial a dose syringe

High-quality veterinary syringes can be cleaned and sterilized, and can be directly filled in the pharmaceutical industry. Plastic syringes have good compatibility and stability. Now syringes are mainly filled with some quality cow mastitis drugs. A trend in the future of pre-filled syringes is to package and store higher value drugs such as biological agents.

The use of plastic syringes can effectively reduce the input cost of the enterprise and eliminate the production costs of washing bottles. 

Secondly, intramammary syringes are safe and reliable, which can effectively reduce cross-infection and secondary infection. The third pre-filled syringe can print the scale on the push rod to ensure the accuracy of the dosage.

dual chamber bottle for liquid

Plastic twin neck bottles are double neck bottles that allow for controlled dispensing as the second chamber eliminates the need for additional measuring. Twin neck bottles are also known as “Bettix Twin Neck Bottles” and are suitable for industrial, agricultural and animal care products. Please note that each bottle requires two caps.

twin neck bottle

A dual chamber bottle is a highly effective container for the storage and distribution of a wide range of herbicides. A professionally designed and manufactured dual chamber bottle is an easy and proficient solution if you have been looking for an effective way to package a liquid and powder product into a single container. This bottle is designed to safely and accurately measure concentrates minimising the risk of spillage.

usage of twin neck bottle

Made from a durable semi-opaque plastic for visibility of liquid with measuring markings up to 100ml. Ideal for accurately measuring chemicals and herbicides.

What is the advantage of rubber and stopper

Aluminum rubber and stopper cap is a kind of medicine packaging material used with oral liquid bottles, which has the following advantages:

vaccine bottle

1. The aluminum cap of the oral liquid bottle has excellent sealability: this is the most basic function as the packaging material, and the most important function. Only a good sealed aluminum lid can guarantee the quality of the drug.

2. Beautiful: Not only reflects the beautiful and generous features, but also highlights the user's level and height.

3. Safety guarantee: The antibacterial aluminum cover will not volatilize or modify the drug, which fully guarantees the safety of users and patients.

4. It has good flexibility and can be compared with rubber cover.

5. The aluminum cap of the oral liquid bottle is not only beautiful, but also protects the content products from damage. Jinyuan oral liquid aluminum cap can be produced according to customer requirements.

6. The aluminum cover is made of high-quality aluminum material, which is hygienic and does not rust. It is easy to open and does not require auxiliary tools. After opening, the bottle cap is destructive and can effectively prevent theft.

Development trend of COP medical bottles

The United States, Canada, Western Europe and Japan accounted for 60% of total pharmaceutical packaging use. Growth was mainly in prescription drugs, over-the-counter medicines, Chinese medicines and health products. The whole trend is to use more secure and reliable packaging materials.

COP bottles are mainly used for high value-added drugs and are very afraid of damage (such as lymphocyte antigens, hormonal drugs, narcotic drugs and items with accurate dosage requirements); drugs with high PH value (greater than 9); easily be glass Surface-adsorbed drugs (such as protein-based biopharmaceuticals, vaccines, etc.); other drugs that are susceptible to oxidation. Medical glass bottles are often broken during transportation, storage, and sales. Glass and special medicines sometimes react. For high-HP drugs, when the HP value is higher than 9, the film will be peeled off and metal ions will be generated. The use of surface adsorption in some biological agents will produce the phenomenon of adsorption.

know more about plastic syringe

First of all, the current perfusion device is mainly made of glass material and plastic material. The plastic perfusion device is gradually replacing the glass syringe. The main cost is lower, the safety is higher than that of the glass syringe, and it is not easy to be broken. The production process of the perfusion device itself is relatively advanced, and the infusion device is generally produced by an injection molding process. The products produced by the injection molding process are molded at one time without any scraps, and the products are accurate in size and uniform in weight.

plastic syringe

Secondly, the sealing requirements of the perfusion product are high. When selecting the perfusion device, the sealing property should be tested. Half of the water is injected into the perfusion device, the piston is inserted into the syringe, the protective cap is removed, and the residual air is removed. Block with the cap and apply an axial pressure of 30 N on the pusher plug inside the syringe through the push rod for 30 seconds. There should be no leakage at the cap seal and the piston seal.

Third, the plastic syringe must be guaranteed to be sterility due to direct contact with the drug. Generally, the syringe should be produced in a clean workshop that meets national standards. In addition, in order to ensure sterility, if the veterinary drug manufacturer has higher sterility. Additional requirements for ethylene oxide sterilization or cobalt 60 irradiation sterilization are required.

know more about plastic syringe

First of all, the current perfusion device is mainly made of glass material and plastic material. The plastic perfusion device is gradually replacing the glass syringe. The main cost is lower, the safety is higher than that of the glass syringe, and it is not easy to be broken. The production process of the perfusion device itself is relatively advanced, and the infusion device is generally produced by an injection molding process. The products produced by the injection molding process are molded at one time without any scraps, and the products are accurate in size and uniform in weight.

plastic syringe

Secondly, the sealing requirements of the perfusion product are high. When selecting the perfusion device, the sealing property should be tested. Half of the water is injected into the perfusion device, the piston is inserted into the syringe, the protective cap is removed, and the residual air is removed. Block with the cap and apply an axial pressure of 30 N on the pusher plug inside the syringe through the push rod for 30 seconds. There should be no leakage at the cap seal and the piston seal.

Third, the plastic syringe must be guaranteed to be sterility due to direct contact with the drug. Generally, the syringe should be produced in a clean workshop that meets national standards. In addition, in order to ensure sterility, if the veterinary drug manufacturer has higher sterility. Additional requirements for ethylene oxide sterilization or cobalt 60 irradiation sterilization are required.

Ceflonin breast injection (dry period) packaging choice!

Ceflorin is a semi-synthetic first-generation cephalosporin antibiotic, currently widely used in the EU and the Commonwealth of Commonwealth countries. It can be used to treat cows’ dry-mastitis and prevent new infections in the breast. Ceflonin has a broad antibacterial spectrum, has strong antibacterial activity against Gram-positive and Gram-negative bacteria, and has a good effect on β-lactamase-producing bacteria. Cephalonin-sensitive bacteria include golden yellow Staphylococcus, Streptococcus agalactiae, Streptococcus uberis, Streptococcus agalactiae, E. coli, etc.

The most commonly used packaging for pre-filled syringes as breast implants has the following characteristics:

1. More accurate doses of medicines During use, there are more residual medicines. Pre-filled syringes can minimize the residues of medicines and the doses are more accurate.

2. Direct injection, to avoid the staff from harming themselves during the dispensing process.

3. Convenient to use, no pollution: the pre-filled liquid medicine only needs to remove the needle cap and directly inject, there is no cross-contamination, the air can’t contact the medicine, and the injection is truly safe.

Ceflonin injection packaged with pre-filled syringes can not only effectively ensure the safety and stability of the drug, but also greatly save medication time. At the same time, soft-headed pre-filled syringes can also effectively reduce the damage to cow breasts.

Effervescent tablet packaging tube cap structure

The tube cap of the effervescent tablet is composed of a low-density polyethylene (LDPE) bottle cap skeleton, desiccant, and a cardboard.Desiccant is used to prevent moisture and mildew in medicine and food. Commonly used desiccants can be divided into physical adsorption desiccants and chemical adsorption desiccants. The silica gel desiccants in physical adsorption desiccants meet the US FDA standards and have been verified to be harmless to the human body. Silica gel desiccant physically adsorbs water molecules into its structure.

Effervescent tablet packaging tube use chemisorbent desiccants. Commonly used desiccants for chemical adsorption are quicklime, magnesium chloride, calcium chloride, soda lime, phosphorus pentoxide, etc., which absorb water molecules to change their chemical structure and become another substance. Molecular sieves are another commonly used desiccant. Molecular sieves are crystalline silicates or aluminosilicates, which are pores and cavities that are connected to each other by oxygen bridge bonds through silicon-oxygen tetrahedra or aluminum-oxytetrahedra. It can be used as efficient desiccant, selective adsorbent, catalyst, ion exchanger, etc. According to the size of the pore channel, molecular sieves with pore size less than 2nm, 2-50nm and more than 50nm are called micropore, mesopore and macropore molecular sieve, respectively.

The cap of the effervescent tablet packaging tube has a spiral plastic spring and the cardboard is used to isolate the desiccant from the medicine to prevent direct contact with the article. The spring can compress the tablet to prevent shaking. Desiccant is on the top of the lid to prevent accidental ingestion. The cap and the bottle are directly matched and sealed, and no gasket is required. The bottle body is mainly injection molding and injection blowing, and the capacity is generally less than 100ml. Can be printed according to customer requirements. Mainly used for testing paper, effervescent tablets easily absorb moisture.

Several key test items for the test paper bottle

The test paper tube mainly refers to the in vitro test strip packaging container, which has strong professional characteristics and guarantees the validity of the test paper. Therefore, the sealing of the bottle body and the bottle cap has a great influence on protecting the validity period of the test strip in vitro. In addition to the sealing and moisture absorption rates, there are several points to be noted in the packaging of qualified test strips:
1. Appearance: uniform color, no damage, no oil, good cooperation
2. Desiccant moisture content: less than 4.8%.
3. anti-drop: desiccant should not spill.
4. Cardboard: The moisture content is less than 6%, there is no fluorescence reaction, and the heavy metal is less than 5 parts per million.
5. the dissolution: heavy metals, easy oxides, non-volatiles.
6. microorganisms: bacteria less than 1000, mold yeast less than 100, Escherichia coli can not be detected.
7. abnormal toxicity can not be detected.
Caps of test strips packaging play a key role - with an integrated desiccant design that helps customers reduce overall costs. The clamshell seal increases consumer appeal and is ergonomically designed to encourage consumers to close the seal and extend protection. Different types and amounts of desiccant can be customized according to customer requirements.

What should you pay attention to when using the syringe?

The perfusion device is generally made of polyethylene material, and its structure is mainly composed of a sleeve, a push rod, a piston, a positioning ring and a protective cap. The perfusion device is mainly sterilized by an ethylene oxide sterilization device, and is sterile and pyrogen free. This type of syringe can be filled with liquid in advance, which is convenient and quick to operate. The veterinary drug market continues to increase its demand!

Note the following when administering with a syringe:
First, you should pay attention to whether the syringe is clean and the package is damaged before using the syringe.
Second, whether the pre-filled drug in the perfusion device is degraded, and whether the drug solution exceeds the expiration date;
Third, whether the syringe use site is disinfected after several injections before injection;
Fourth, take corresponding measures according to the situation of sick animals;

New requirements for candy tablet packaging of health products - moisture-proof drying

The health care candy tablet refers to the health care product produced by the candy tableting process, usually generally a tablet. The purpose of the tableting process for health care products is to make the health care products tablets have a better taste and improve the user's eating experience.

At present, the candy tableting industry is gradually adopting moisture-proof dry bottles. This kind of packaging has good sealing performance and integrates desiccant into the bottle cap, which can effectively prevent the tablets from contacting the desiccant and can achieve the purpose of absorbing water molecules, so as to keep the packaging drying inside.

The health care candy tablet packaging tube cap has a small store box to store the desiccant which can prevent the candy tablet from moisture.The desiccant is on the top of the lid, and the lid is directly sealed with the tube body without the need for a gasket. The cap is made by injection molding, and the bottle body is injection-blasted. The general capacity is less than 100ml. Printing can be done according to customer requirements.

The new effervescent tablet packaging caps are designed with an integrated desiccant to help customers reduce overall costs. The clamshell seal increases consumer appeal and is ergonomically designed to encourage consumers to close the seal and extend protection.

The source of moisture and the number of water molecules in effervescent tablet tube

There are several sources of moisture in effervescent tablet tube：
First, the effervescent tablet tube's body and the cap material itself have a certain amount of moisture.
Second, the evaporation of water in the medicine and packaging materials during the production process and storage.
Third, the moisture contained in the medicine itself.
Fourth, the moisture contained in the air in the packaging after the packaging container is sealed.
Fifth, after sealing, the water molecules in the external atmosphere penetrate into the product during transportation and storage.
Physically adsorbing water molecules into their structures, or chemically absorbing water molecules and changing their chemical structure to become another substance.
Influence factors of water molecules number in the effervescent tube:
1.The size of the packaging container (dry space), the humidity requirements of the packaged product (the relative humidity of the predetermined control)
2.the water content of the product itself
3. The properties of the packaging materials used in the product (especially moisture permeability)
4.the level of sealing of the product packaging
5.The temperature and humidity of the environment when the product is packaged, the shelf life of the product, the environment and climatic conditions for product transportation and storage, etc.
6.the absorbency of the desiccant

Biologics packaging - COP vials

With the continuous development of biopharmaceutical technology,the COP vials are used more and more widely.

COP vials are made from a cyclic olefin polymer (COP); polymers are considered to be more stable materials than glass compared to glass. Compared with most glass bottles, COP has no protein adsorption, which can guarantee the content of active ingredients in medicines. Due to the use of polymer material properties, it has a high-end positioning in the industry compared to most vials. It is especially suitable for complex molecules and sensitive drugs that require high stability.

What are the main factors in the storage management of veterinary medicine?

The quality of veterinary medicines includes the intrinsic quality, appearance quality and packaging quality of the drugs. The appearance quality of a drug refers to the physical and biological properties of the drug, such as color, odor, crystal or insoluble matter, morphology, solubility, weathering, deliquescence, mildew, insects and so on.
1.visual inspection: 1 inspection of packaging, containers and labels; 2 inspection of raw materials; 3 inspection of various preparations.
2. Factors affecting the deterioration of drugs:

• Air: The oxygen in the air can cause many of the reducing agents to oxidize and produce toxicity, such as oil rancidity; carbon dioxide in the air makes the sulfa drug carbonate.
• Light: Ultraviolet rays can cause many drugs to undergo chemical reactions such as discoloration, oxidation, reduction and decomposition. For example, silver nitrate and mercury are photosynthetically reduced to precipitate dark brown toxic silver and mercury.
• Temperature: The increase of temperature can accelerate the volatility of the drug, and more importantly, it can promote chemical reactions such as oxidation and decomposition to accelerate the deterioration of the drug. For example, serum, vaccine and organ preparations are easy to be stored at room temperature, and need to be refrigerated at low temperature; The increase in temperature also tends to soften the ointment and capsules, and accelerate the volatilization of volatile drugs. However, if the temperature is too low, some drugs or preparations will be used to precipitate. For example, formaldehyde will form a polymeric precipitate under 9 ° C to precipitate a white precipitate; low temperature will also cause the liquid drug to freeze, causing the container to rupture.
• Humidity: The water vapor content in the air is called humidity. Humidity is the most variable part of the air and fluctuates with the region, season and temperature. Humidity has a great impact on drug storage. If the humidity is too large, the drug can absorb moisture and deliquesce, dilute, deform, and mold; the humidity is too small, and the drug containing crystal water is easily weathered (loss of crystal water).
• Microorganisms and insects: When drugs are exposed to the air, they are metabolized by microorganisms and insects, causing deterioration, fermentation, mildew and insects.
• Time: Any medicine that has been stored for too long will deteriorate, but different medicines will change at different speeds. Antibiotics, biological agents, organ preparations and certain chemicals are all valid and must be used within the validity period.

Pets feeding syringe sealability factor

The three influencing factors of pets feeding syringe are barrier properties, sealing methods, and density of feeders. These points will have a certain impact on the sealing effect of the pets feeding syringe.
1. Barrier performance of pet feeding syringe:
The barrier criteria are mainly the O2 transmittance and the water vapor transmission rate of the material. The barrier properties of the substrate will directly affect the quality of the drug during the shelf life, and it is also an important indicator for assessing the shelf life of the drug.
2. Sealing method
There are three main types of sealing methods:
The first is to seal the outer thread of the bottle with the inner thread of the bottle cap;
The second is to use the flat pressure seal, with the capping of the bottle cap, the surface of the bottle mouth and the inside of the bottle cap The gasket is contacted to achieve the sealing;
The third is the cap sealing. During the capping process, the cap with the inverted cone or the elliptical body plug is pressed into the interior of the bottle mouth, relying on the interference between the inner plug and the inner diameter of the bottle mouth. Cooperate to achieve sealing. Which sealing method is used depends mainly on the nature of the contents of the bottle.
3. The density of the pets feeding syringe
The density of pet feeders is closely related to their barrier properties and mechanical properties, and is an important basic parameter affecting the physical properties of materials. By comparing the test results of three common substrates of PP, HDPE and PET, the density of all three substrates is within the national standard.

Plastic paste syringe is a highly efficient and practical injection device

In recent years, the packaging of pharmaceuticals has shifted to refined, low-dose packaging. Plastic paste syringes combine “storing drugs” with “injection functions” to make them safer, more precise and less polluting. The plastic paste syringe is a new, practical, new type of injection.

The traditional injection method may cause contamination of the liquid medicine due to improper operation during the injection process, and the plastic paste syringe can provide a more efficient and economical drug delivery method. Precise medication, high drug use rate, safe drug delivery and other advantages. Received universal recognition and application. The veterinary plastic syringe abandons the cumbersome operation of the penetrating injection method, allowing the drug solution to be injected in one step. It has been adopted by more and more veterinary drugs companies.

Every part of the plastic paste syringe is produced with advanced equipment and production technology, and strives for excellence. The product has the characteristics of being not easily broken, the surface is smooth and smooth, and the medicine is safe, more efficient and economical.

Do you understand these three characteristics of plastic veterinary paste syringes?

The plastic veterinary paste syringe is a new type of pharmaceutical packaging container with high technical content, and suitable for injection and injection.Mainly used for the treatment of cow mastitis, and creamy medicine.The paste injector is to directly inject the injected medicine into the syringe, and the syringe and the medical liquid packaging container are combined into one, and the injection is directly used, which is very convenient.Plastic veterinary paste syringes have the following outstanding features:
1. The dosage is more accurate. There are more residual liquids during use, and the plastic syringe can minimize the residual of the liquid, and the dosage is more accurate.
2. Direct injection, to avoid the staff to cause harm to themselves during the dispensing process.
3. Easy to use, no pollution: When pre-filled liquid is used, only the needle cap needs to be taken off, directly injected, no cross-contamination, and the air is not exposed to the medicine, so that the safe injection is achieved.
The plastic veterinary paste syringe produced by the animal health company can be used directly, which solves this problem well. A dose of the drug has been included in each plastic syringe and can be discarded directly after use, avoiding the potential contamination of the drug into the syringe during regular injections.

plastic veterinary paste syringe

How is the pet feeding syringe sterilized?

With the continuous development of the pet industry, the pet feeding syringe has also been continuously improved.The pet feeding syringe has a simple structure, which is mainly composed of syringe barrel, plunger, tip cap and piston.The plunger can print a scale, which can effectively ensure feeding.

The aseptic processing of pet feeding syringes mainly involves the sterilization of ethylene oxide and cobalt 60. The sterilization of ethylene oxide is mainly gas sterilization. Currently, medical devices are widely sterilized by ethylene oxide. Cobalt 60 sterilization is radiation sterilization, which is relatively costly. The main advantages of both are as follows:

Ethylene oxide sterilization for pet feeding syringe has several advantages:
1. Can kill all microorganisms, including bacterial spores.
2. Sterilized items can be wrapped, packaged in their entirety, and kept sterile before use.
3. Does not corrode plastic, metal and rubber;
4. Can penetrate irregular shapes products

The advantages of cobalt 60 sterilization for irradiation sterilization are:
1. The penetrating power is very strong, and it is not necessary to disassemble the product packaging during irradiation, which can ensure that all parts of the product are uniformly irradiated, and the sterilization effect can be achieved.
2. Irradiation sterilization is carried out under normal temperature and normal pressure, no residue, no pollution, no residue, convenient and fast.

The child resistant cap bottle with desiccant cap

The new design of the child proof bottle is based on safety and prevents people other than the patient from eating, especially in children and mental patients.
At present, ordinary packaging bottles are generally sealed by aluminum foil gaskets to ensure the sealing property, but after the gasket is opened, the sealing effect is not guaranteed, and the tablets and capsules are frequently opened in the bottle cap, and the sealing is not good. Will cause the drug to absorb water or oxidize. Therefore, relying mainly on gasket sealing, there are great hidden dangers. Secondly, when the cap is frequently opened, moisture will invade the bottle and accelerate the deterioration of the drug. In particular, such as aspirin, sodium phenobarbital, effervescent tablets, test strips, etc., are prone to deformation or deterioration after moisture absorption, and must be packaged in a bottle with good sealing properties.
Therefore, the special point of the special screw cap safety bottle is combined with the dual function of preventing moisture and opening, ensuring that the medicine remaining in the bottle after opening is still in a relatively sealed state during the use of the medicine; The risk of children accidentally opening and eating drugs.

The child resistant cap bottle with desiccant cap

how to test the sealing of packaging container(veterinary syringe) in UPS

how to test the sealing of packaging container(veterinary syringe) in UPS
The sealing of packaging container is a topic which is concerned by pharmaceutical workers,the traditional test methods have some cons,like
material wastage much,unidentified the leak level and so on.So many countries are being developed new test methods.The UPS 1207 of USA  put forward multiple test measures,such as pressure/vacuum decay, tracer gas detection,electrion process and laser method.
Then i will detailedly introduce the three major test methods,vacuum decay,Electrical Conductivity and Capacitance Test and Laser-based Gas Headspace Analysis.

1. vacuum decay,the theory of vacuum decay is that put packaging container in the special test chamber,vacuumize the chamber,the air of the packaging container will enter into the test chamber on account of inner and outer pressure difference,the pressure sensor will detect the pressure change,then compare the pressure changing value with reference value,then you can judge the packaging container whether qualified.The vacuum decay method is a nondestructive and quantitative assay (USP <1207.2>). It detects leaks in nonporous, rigid or flexible packages. Packages with a porous component can be tested by masking the porous package component (USP <1207.2>). The test sample is placed in a closely fitting evacuation test chamber, which is equipped with an external vacuum source (USP <1207.2>). The test chamber plus test system dead space are evacuated for a predetermined period of time (USP <1207.2>). The targeted vacuum level chosen for the test is predetermined on the basis of the test sample type under evaluation (USP <1207.2>). The rise in dead space pressure (i.e., vacuum decay) is monitored for a predetermined length of time using absolute and/or differential pressure transducers (USP <1207.2>). A pressure increase that exceeds a predetermined pass/fail limit established using negative controls indicates container leakage (USP <1207.2>).
2. Electrical Conductivity and Capacitance Test.The Electrical Conductivity and Capacitance Test is also known as High Voltage Leak Detection (HVLD). This assay looks for leaks in walls of nonporous, rigid or flexible packaging containing liquid or semi-liquid product (e.g. ampoules) (USP <1207.2> ). During the assay, a high voltage and high frequency charge is applied across the containerclosure system (White, 2012). A detected leak will cause an increase in current across the high voltage electrodes, triggering the reject mechanism for the leak detector (White, 2012). Key factors for the assay include the voltage level, probe positioning, the container-closure system geometry, the wall thickness, and the product formulation.
3. Laser-based Gas Headspace Analysis.According to detect the change of the pressure,water vapour and oxygen gas of gas headspace of packaging container,to judge the completeness of plastic bottles.The theory is that when the laser penetrate the gas headspace of packaging container,the water vapour and oxygen gas will absorb some laser,the laser absorptive amount is proportional to corresponding matter content.

What test methods can be choose to test the common packaging container.

1. syringe can choose the vacuum decay and electrical conductivity and capacitance test
2. vaccine bottle can choose the vacuum decay,electrical conductivity and capacitance test,Laser-based Gas Headspace Analysis
3. the eye dropper bottle can choose the vacuum decay and electrical conductivity and capacitance test
4. the effervescent tube can choose the vacuum decay and electrical conductivity and capacitance test

The new material vial - cyclo olefin polymer (cop) bottle

First,what is the COP material?
The cyclo olefin polymer (cop) material is a lightweight, breakage-resistant packaging for protein-based, peptide-based, floating particle, and high-viscosity drugs, this plastic material is suitable for use in prefilled syringes and vials where transparency, sterilization, breakage-resistance, and stability are important.
Second,The sterilization method of COP vial.
COP can be through steam-, ethylene oxide-, and gamma-sterilization without any significant change.
Third, the advantages of the COP material vial

As with most other packaged goods pharmaceuticals need reliable and speedy packaging solutions that deliver a combination of product protection, quality, tamper evidence, patient comfort and security needs. Constant innovations in the pharmaceuticals themselves (such as prefilled syringes, blow fill seal vials, powder applications and others) also have a direct impact on the pharmaceutical packaging.

The advantages of twin neck bettix bottle

High density polyethylene (HDPE ) is the most commonly used resin. This economical plastic has good impact resistant, is naturally translucent, flexible, and typically used for personal care products, such as shampoo bottles. Adding color will give HDPE an opaque look that will result in an increase in weight and rigidness.
Plastic twin neck bottles are double neck bottles that allow for controlled dispensing and the second chamber eliminates the need for additional measuring. Double neck bottle is suitable for industrial, agricultural and animal care products.
HDPE liquid bottle has two chambers, one for storing and the other for measuring exact doses. The second chamber is designed to eliminate additional measuring by providing precise pouring every time.
To use, squeeze the bottle to fill the measuring chamber with desired amount of liquid. Then, remove the cap and easily pour measured liquid from the chamber. The twin neck bottle is often used for industrial, as well as agricultural and animal care products.

The structure of effervescent tablet tube's desiccant cap

The effervescent tablet tube's desiccant cap serves as a container for protecting medicines from moisture or damage to medicines, health foods and diagnostic products. The bottle body and cap form a sealing system to prevent sensitive products from getting wet, prolong the shelf life and enhance brand value. The moisture-proof combination bottle body and cap use special design features and plastic materials to prevent moisture from entering and absorb moisture generated by water vapor transmission effect. The moisture-proof combination cover features include:
1. Anti-theft ring: There is no bottle buckle at the bottle neck. When the moisture-proof cover is covered, the anti-theft ring will be stuck. When it is opened, the anti-theft ring will automatically fall off.
2. Sealing: It adopts double material system (polyethylene cap and polypropylene bottle body) and innovative shaping design. The sealing and container are perfectly sealed, and the water vapor transmission effect is strictly controlled.
3, cork spring: optional cap to ensure that the tablet does not shift, especially during transportation, to avoid the bumps affected by the bumps
4, desiccant: the desiccant chamber of the bottle cap can be used to match the desiccant of various types, quantities and attributes to ensure that the product is properly protected.

The productive process of veterinary vaccine injection bottle

The production cycle of veterinary vaccine bottle which is produce by injection moulding is short and high efficiency,The injection moulding technology can produce complex shape bottle,high-precision size plastic bottles.These bottle can't be easily produced by other forming methods,so many plastic bottle factory use the injection moulding technology to produce their bottls,in the second place,the injection moulding technology can easilly realize automation,such as injection process,demould process and cutting pouring gate all can realize automation,so the injection moulding is used more and more widely.

Today i will introduce the productive process of veterinary vaccine bottles.

The veterinary vaccine bottle's injection moulding theory is that fill the powdery or granuliform PE or PP raw material in the gunk of injection machine,this raw material is heated and melted in injection machine and keep the raw material flowing,then the injection machine inject the flowing liquid raw material to the closed mould,then cooling the raw material,the melted raw material will solidify,and you can get the veterinary vaccine bottle.

The injection moulding technology also has some disadvantages,first,the injection equipments is higher,second the structure of mould is complex and the produce cost is higher,so this process is not suitable for small amount produce.

The followings are some notices when you are in the injection moulding process.

Before starting the produce the vaccine bottle,you need preheat and dry the raw material,wipe off the redundant moisture and volatile matter,if you do like this,you can prevent that the plastic bottle degrades and has imperfection which can influence the appearance and quality
when you change raw material or product,you need wash the charging barrel
The finally,i will integrally introduce the injection moulding

set the injection moulding parameter,like temperature,pressure and time
prepare the injection mould,prepare the mold carefully keeping the dimensions and specifications in check
injection the molten plastic,
packing of the mold
cooling of the mold
ejection of the mold
These are productive process of veterinary vaccine bottle.

What May Cause Desiccant Tube Date Error

The reason of desiccant tube date error has been confiromed. Confirmation is not laboratory test error caused by excessive, is indeed the quality of products after exceeding the standard. The investigation phase of exceeding standard is transferred from the quality control laboratory to the production related department, and the reasons can be divided into the following three kinds:
First, deviation of non production process: deviation of test results caused by operator's failure to operate equipment or wrong material.The deviation is investigated by professionals in the quality department, the production department or the equipment management department.
Second, production process deviation refers to the deviation of the inspection results caused by the defects of the production process, even if the personnel operation, equipment and materials are correct. The deviation should be investigated by professionals familiar with and familiar with the process technology.
Third, if the material itself brings the deviation, the survey is divided into two cases: first, the factory inspection deviation. First of all by the quality department and supply department investigation, receiving temporary process if there is deviation, the absence of such a material manufacturer shall notify the investigation of its production and storage process without bias, and investigate whether there is any deviation in the transport process.The two is if the factory inspection qualified, in the use or storage process deviation, should be the quality department and supply department investigation storage conditions and weighing process whether there is deviation.
The data record is clear, do not do well documented, product appearance, desiccant tube manufacturers can gain a foothold in the messy.

What should we pay more attention on choosing plastic pharma bottle

Child resistant cap bottle mainly keep safe and prevent healthy people eatting by mistake, especially for children and psychopath. However desiccant bottle can offer dry condition for tablets. Today we talk something about plastic pharma bottle.
Recently general plastic pharma bottle adopts the way of aluminum foil gasket seal to keep sealing. However after opening the gasket, sealing effect can not be get guarantee. The cap of tablets and capsules need to be opened frequently and the sealing is bad, which will cause drug absorption or oxidative deterioration. So there is a big hidden danger replying on gasket sealing. Second, when the cap is opened frequently, humidity will come into plastic bottle, and then speed up drug metamorphic. Especially for effervescent tablets, test strip and so on, it will be out of shape or go bad after moisture absorption. Excellent sealing bottle is important for tablets and capsules.
So point of special child resistant cap bottle is having moisture proof, child resistant and desiccant cap can gurantee the drugs in the bottle can remain relatively sealed after opening, when using drugs. In order to prevent children opening and eating by mistake dangeriously. Recently the plastic pharma bottle has applied for national patent.
The invention relates to the special structure of the bottle cap of the packaging bottle to achieve the purpose of the invention. The patent bottle cap is bilayer structure and equipped with child resistant cap, excellent sealing due to drug storehouse on the cap top, which can store desiccant and oxygen absorbent.

The introduce of child resistant cap bottle

Child resistant cap bottle is aslo called CRC bottle, it is a necessary packaging for drug. It is safe for family who has children, especially for baby who can not distingwish anything. Children may eat tablets by mistake if open the pharma bottle.

Pharma bottle with child resistant cap is contain with bottle and cap. The special design is the double cover, inner cap and thread of bottleneck connected, cover and inside links,it need external force to press the cover and turn to open. Which need people push down and turn can open the bottle. It adopts advanced injection blow molding which makes even bottleneck and uniform wall thickness.

Excellent sealing and high security show the good quality. Child resistant cap is mainly used in medical and health care to prevent children eating pills or food by mistake.

Effervescent Tablet Tube Test

The concept of the inspection result exceeding standard management was introduced for the first time, which means that the test result is beyond the legal standard and the enterprise internal control standard. Excessive inspection results do not necessarily mean that the sample inspection is not qualified. How can the effervescent tablet tube manufacturer be implemented?

First, the operating procedures for the establishment of inspection results exceeding the limits of the investigation within the company. Laboratory investigation was carried out according to the regulations to confirm whether it was laboratory bias. If it is not the laboratory deviation, the R & D, technology and production personnel should be organized to investigate the production process. It can also be interpreted as two categories: laboratory bias and non laboratory bias.

The laboratory deviation shall investigate any deviation of the test results caused by the factors related to the inspection process,A laboratory survey should be carried out by the professional personnel. The non laboratory deviation refers to the deviation of the test results caused by any other factors except the deviation of the laboratory. The above deviation analysis also standardizes the concrete implementation of the inspection results exceeding the standard for effervescent tablet tube factory.

The desiccant packaging of effervescent tablet

It is well known for people that the effervescent tablet can react with water,so when you store the effervescent table, you need avoid the moisture of air.And the effervescent tablet tube can ensures optimal performance of effervescent tablets, effervescent packaging consists of one-piece, flip-top desiccated vials, and desiccated bottles across a range of sizes.

Effervescent tablets packaging adopts plastic tube and desiccant caps to achieve moisture protection, this design is conventient for customers to carry anywhere, the tube diamater is suitable for effervescent tablets or supplements, the length can be suitable for 10pcs, 20pcs tablets, of course we can slao offer customization for your products. Desiccant cap according to user-friendly design, there are small hand pattern on the top of the cap, which can make users know how to open the cap easily, there is also has open design for hands. There are desiccant container and spring ring inside the cap, desiccant including silica and molecular sieve, which can keep the tube in dry environment, while spring ring can prevent the tablets damaging during the transport.