Thursday, October 17, 2019

What are the main factors in the storage management of veterinary medicine?

The quality of veterinary medicines includes the intrinsic quality, appearance quality and packaging quality of the drugs. The appearance quality of a drug refers to the physical and biological properties of the drug, such as color, odor, crystal or insoluble matter, morphology, solubility, weathering, deliquescence, mildew, insects and so on.
1.visual inspection: 1 inspection of packaging, containers and labels; 2 inspection of raw materials; 3 inspection of various preparations.
2. Factors affecting the deterioration of drugs:
  • Air: The oxygen in the air can cause many of the reducing agents to oxidize and produce toxicity, such as oil rancidity; carbon dioxide in the air makes the sulfa drug carbonate.
  • Light: Ultraviolet rays can cause many drugs to undergo chemical reactions such as discoloration, oxidation, reduction and decomposition. For example, silver nitrate and mercury are photosynthetically reduced to precipitate dark brown toxic silver and mercury.
  • Temperature: The increase of temperature can accelerate the volatility of the drug, and more importantly, it can promote chemical reactions such as oxidation and decomposition to accelerate the deterioration of the drug. For example, serum, vaccine and organ preparations are easy to be stored at room temperature, and need to be refrigerated at low temperature; The increase in temperature also tends to soften the ointment and capsules, and accelerate the volatilization of volatile drugs. However, if the temperature is too low, some drugs or preparations will be used to precipitate. For example, formaldehyde will form a polymeric precipitate under 9 ° C to precipitate a white precipitate; low temperature will also cause the liquid drug to freeze, causing the container to rupture.
  • Humidity: The water vapor content in the air is called humidity. Humidity is the most variable part of the air and fluctuates with the region, season and temperature. Humidity has a great impact on drug storage. If the humidity is too large, the drug can absorb moisture and deliquesce, dilute, deform, and mold; the humidity is too small, and the drug containing crystal water is easily weathered (loss of crystal water).
  • Microorganisms and insects: When drugs are exposed to the air, they are metabolized by microorganisms and insects, causing deterioration, fermentation, mildew and insects.
  • Time: Any medicine that has been stored for too long will deteriorate, but different medicines will change at different speeds. Antibiotics, biological agents, organ preparations and certain chemicals are all valid and must be used within the validity period.

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