Monoclonal antibody application for listing, COP bottle market will usher in growth

 On November 8, the CDE official website showed that the application for the marketing of biosimilar biosimilars of Biotetozumab was accepted by the State Food and Drug Administration. The research and development of domestic monoclonal antibody drugs has been gradually applied for the market from the clinical stage, and COP bottles, as an important packaging form of such drugs, will also usher in growth under the influence of the industry.

5ml COP vial

100ml COP injection vial

Tocilizumab injection (tocilizumab) was developed by Chugai Pharmaceutical (Roche). It is a humanized anti-human interleukin 6 receptor (IL-6R) monoclonal antibody preparation expressed in mammalian cells (CHO). Named: Actemra (Actemra). Tocilizumab can block the binding of interleukin 6 to the soluble and membrane-bound interleukin 6 receptor and inhibit the signal transduction of interleukin 6, thereby reducing pathological inflammation.

At present, there are two indications approved for the study of Tocillin antigen in my country, namely: adult rheumatoid arthritis and systemic juvenile idiopathic arthritis. As tocilizumab injection's original molecular protection patent has expired, domestic and foreign pharmaceutical companies have devoted themselves to the research and development of their biosimilar drugs. CDE official website data shows that as of November 10, the number of new drugs declared for marketing in 2021 has reached 104, which shows that Chinese pharmaceutical companies are making rapid progress in the research and development of monoclonal antibody drugs, and the industry is about to usher in a period of stable development. The development of the industry will inevitably drive the prosperity of its upstream and downstream industrial chains, such as COP vials and other pharmaceutical packaging.

COP vial is a plastic bottle made of cycloolefin polymer added with organic solvent and processed by injection stretch blowing process. It has the characteristics of strong temperature resistance, low protein adsorption, low birefringence, high rigidity, and high transparency. It is a common packaging for monoclonal antibodies and other biological drugs. With the rapid development of the industry, this kind of packaging will also usher in an increase in market demand.

Note: Part of the content is derived from Medicine Rubik's Cube Info

Biologics packaging - COP vials

With the continuous development of biopharmaceutical technology,the COP vials are used more and more widely.

COP vials are made from a cyclic olefin polymer (COP); polymers are considered to be more stable materials than glass compared to glass. Compared with most glass bottles, COP has no protein adsorption, which can guarantee the content of active ingredients in medicines. Due to the use of polymer material properties, it has a high-end positioning in the industry compared to most vials. It is especially suitable for complex molecules and sensitive drugs that require high stability.

Plastic COP vials with low protein adsorption

Expensive medicine mainly need spical packaging to protect its’ effectiveness, like cosmetic medicine, oncology drug, cancer drug, etc. These medicine need speical packaging to keep active effect. Many these medicine use glass vials as packaging, howerver there always some more questions troubled the medicine. Like protein adsorption, glass shards, metal ions and so on.

A new material has appeared-Cyclo Olefin Polymer, a plastic material. COP vials as a new packaging in pharmaceutical packaging, some advantages below.
First, High transparency.

Second, tougher break resistance.

Third, high moisture barrier.

Fourth, various sterilization.

Fifth, excellent chemical resistance with low protein adsorption.

Sixth, no metal ions precipitation.
COP is a high performance thermoplastic that overcomes limitations of traditional packagingmaterials with its enhanced barrier, transparency, purity and strength properties. It is an ideal material for contrast media cartridge, prefilled syringes, medicine vial and other pharmaceutical packaging applications.

COP Injection Vials Manufacturer

COP injection vials raw material is Cyclo Olefin Polymer, also called it Zeonex(ZX), which is only offered Xinfuda in China so far and some European industry like West, BD, HPT, Doctor pack, etc, which material offered by Daikyoseiko. COP as a new medical packaging in pharmaceuticals industry, Xinfuda as one of the pharmaceutical packaging industry is always in the front of the science and technology. 

 

 COP injection vials

 

bottleneck

COP injection vials as a new pharmaceutical packaging are popular among the pharma industry, due to the characteristic of COP vial, first is that ultra-cold storage, which deal with many problems about medicine storage. Second is that low protein adsorption, which can store cancer drugs and other expensive medicine, such as Dermatology and Cosmetology, Diabetes, Oncology, Antiretroviral, HIV/AIDS and so on. Third is that transparent high.

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