Effervescent tablet packaging tube cap structure

The tube cap of the effervescent tablet is composed of a low-density polyethylene (LDPE) bottle cap skeleton, desiccant, and a cardboard.Desiccant is used to prevent moisture and mildew in medicine and food. Commonly used desiccants can be divided into physical adsorption desiccants and chemical adsorption desiccants. The silica gel desiccants in physical adsorption desiccants meet the US FDA standards and have been verified to be harmless to the human body. Silica gel desiccant physically adsorbs water molecules into its structure.

Effervescent tablet packaging tube use chemisorbent desiccants. Commonly used desiccants for chemical adsorption are quicklime, magnesium chloride, calcium chloride, soda lime, phosphorus pentoxide, etc., which absorb water molecules to change their chemical structure and become another substance. Molecular sieves are another commonly used desiccant. Molecular sieves are crystalline silicates or aluminosilicates, which are pores and cavities that are connected to each other by oxygen bridge bonds through silicon-oxygen tetrahedra or aluminum-oxytetrahedra. It can be used as efficient desiccant, selective adsorbent, catalyst, ion exchanger, etc. According to the size of the pore channel, molecular sieves with pore size less than 2nm, 2-50nm and more than 50nm are called micropore, mesopore and macropore molecular sieve, respectively.

The cap of the effervescent tablet packaging tube has a spiral plastic spring and the cardboard is used to isolate the desiccant from the medicine to prevent direct contact with the article. The spring can compress the tablet to prevent shaking. Desiccant is on the top of the lid to prevent accidental ingestion. The cap and the bottle are directly matched and sealed, and no gasket is required. The bottle body is mainly injection molding and injection blowing, and the capacity is generally less than 100ml. Can be printed according to customer requirements. Mainly used for testing paper, effervescent tablets easily absorb moisture.

Several key test items for the test paper bottle

The test paper tube mainly refers to the in vitro test strip packaging container, which has strong professional characteristics and guarantees the validity of the test paper. Therefore, the sealing of the bottle body and the bottle cap has a great influence on protecting the validity period of the test strip in vitro. In addition to the sealing and moisture absorption rates, there are several points to be noted in the packaging of qualified test strips:
1. Appearance: uniform color, no damage, no oil, good cooperation
2. Desiccant moisture content: less than 4.8%.
3. anti-drop: desiccant should not spill.
4. Cardboard: The moisture content is less than 6%, there is no fluorescence reaction, and the heavy metal is less than 5 parts per million.
5. the dissolution: heavy metals, easy oxides, non-volatiles.
6. microorganisms: bacteria less than 1000, mold yeast less than 100, Escherichia coli can not be detected.
7. abnormal toxicity can not be detected.
Caps of test strips packaging play a key role - with an integrated desiccant design that helps customers reduce overall costs. The clamshell seal increases consumer appeal and is ergonomically designed to encourage consumers to close the seal and extend protection. Different types and amounts of desiccant can be customized according to customer requirements.

What should you pay attention to when using the syringe?

The perfusion device is generally made of polyethylene material, and its structure is mainly composed of a sleeve, a push rod, a piston, a positioning ring and a protective cap. The perfusion device is mainly sterilized by an ethylene oxide sterilization device, and is sterile and pyrogen free. This type of syringe can be filled with liquid in advance, which is convenient and quick to operate. The veterinary drug market continues to increase its demand!

Note the following when administering with a syringe:
First, you should pay attention to whether the syringe is clean and the package is damaged before using the syringe.
Second, whether the pre-filled drug in the perfusion device is degraded, and whether the drug solution exceeds the expiration date;
Third, whether the syringe use site is disinfected after several injections before injection;
Fourth, take corresponding measures according to the situation of sick animals;

New requirements for candy tablet packaging of health products - moisture-proof drying

The health care candy tablet refers to the health care product produced by the candy tableting process, usually generally a tablet. The purpose of the tableting process for health care products is to make the health care products tablets have a better taste and improve the user's eating experience.

At present, the candy tableting industry is gradually adopting moisture-proof dry bottles. This kind of packaging has good sealing performance and integrates desiccant into the bottle cap, which can effectively prevent the tablets from contacting the desiccant and can achieve the purpose of absorbing water molecules, so as to keep the packaging drying inside.

The health care candy tablet packaging tube cap has a small store box to store the desiccant which can prevent the candy tablet from moisture.The desiccant is on the top of the lid, and the lid is directly sealed with the tube body without the need for a gasket. The cap is made by injection molding, and the bottle body is injection-blasted. The general capacity is less than 100ml. Printing can be done according to customer requirements.

The new effervescent tablet packaging caps are designed with an integrated desiccant to help customers reduce overall costs. The clamshell seal increases consumer appeal and is ergonomically designed to encourage consumers to close the seal and extend protection.

The source of moisture and the number of water molecules in effervescent tablet tube

There are several sources of moisture in effervescent tablet tube：
First, the effervescent tablet tube's body and the cap material itself have a certain amount of moisture.
Second, the evaporation of water in the medicine and packaging materials during the production process and storage.
Third, the moisture contained in the medicine itself.
Fourth, the moisture contained in the air in the packaging after the packaging container is sealed.
Fifth, after sealing, the water molecules in the external atmosphere penetrate into the product during transportation and storage.
Physically adsorbing water molecules into their structures, or chemically absorbing water molecules and changing their chemical structure to become another substance.
Influence factors of water molecules number in the effervescent tube:
1.The size of the packaging container (dry space), the humidity requirements of the packaged product (the relative humidity of the predetermined control)
2.the water content of the product itself
3. The properties of the packaging materials used in the product (especially moisture permeability)
4.the level of sealing of the product packaging
5.The temperature and humidity of the environment when the product is packaged, the shelf life of the product, the environment and climatic conditions for product transportation and storage, etc.
6.the absorbency of the desiccant

Biologics packaging - COP vials

With the continuous development of biopharmaceutical technology,the COP vials are used more and more widely.

COP vials are made from a cyclic olefin polymer (COP); polymers are considered to be more stable materials than glass compared to glass. Compared with most glass bottles, COP has no protein adsorption, which can guarantee the content of active ingredients in medicines. Due to the use of polymer material properties, it has a high-end positioning in the industry compared to most vials. It is especially suitable for complex molecules and sensitive drugs that require high stability.

What are the main factors in the storage management of veterinary medicine?

The quality of veterinary medicines includes the intrinsic quality, appearance quality and packaging quality of the drugs. The appearance quality of a drug refers to the physical and biological properties of the drug, such as color, odor, crystal or insoluble matter, morphology, solubility, weathering, deliquescence, mildew, insects and so on.
1.visual inspection: 1 inspection of packaging, containers and labels; 2 inspection of raw materials; 3 inspection of various preparations.
2. Factors affecting the deterioration of drugs:

• Air: The oxygen in the air can cause many of the reducing agents to oxidize and produce toxicity, such as oil rancidity; carbon dioxide in the air makes the sulfa drug carbonate.
• Light: Ultraviolet rays can cause many drugs to undergo chemical reactions such as discoloration, oxidation, reduction and decomposition. For example, silver nitrate and mercury are photosynthetically reduced to precipitate dark brown toxic silver and mercury.
• Temperature: The increase of temperature can accelerate the volatility of the drug, and more importantly, it can promote chemical reactions such as oxidation and decomposition to accelerate the deterioration of the drug. For example, serum, vaccine and organ preparations are easy to be stored at room temperature, and need to be refrigerated at low temperature; The increase in temperature also tends to soften the ointment and capsules, and accelerate the volatilization of volatile drugs. However, if the temperature is too low, some drugs or preparations will be used to precipitate. For example, formaldehyde will form a polymeric precipitate under 9 ° C to precipitate a white precipitate; low temperature will also cause the liquid drug to freeze, causing the container to rupture.
• Humidity: The water vapor content in the air is called humidity. Humidity is the most variable part of the air and fluctuates with the region, season and temperature. Humidity has a great impact on drug storage. If the humidity is too large, the drug can absorb moisture and deliquesce, dilute, deform, and mold; the humidity is too small, and the drug containing crystal water is easily weathered (loss of crystal water).
• Microorganisms and insects: When drugs are exposed to the air, they are metabolized by microorganisms and insects, causing deterioration, fermentation, mildew and insects.
• Time: Any medicine that has been stored for too long will deteriorate, but different medicines will change at different speeds. Antibiotics, biological agents, organ preparations and certain chemicals are all valid and must be used within the validity period.