The source of moisture and the number of water molecules in effervescent tablet tube

There are several sources of moisture in effervescent tablet tube：
First, the effervescent tablet tube's body and the cap material itself have a certain amount of moisture.
Second, the evaporation of water in the medicine and packaging materials during the production process and storage.
Third, the moisture contained in the medicine itself.
Fourth, the moisture contained in the air in the packaging after the packaging container is sealed.
Fifth, after sealing, the water molecules in the external atmosphere penetrate into the product during transportation and storage.
Physically adsorbing water molecules into their structures, or chemically absorbing water molecules and changing their chemical structure to become another substance.
Influence factors of water molecules number in the effervescent tube:
1.The size of the packaging container (dry space), the humidity requirements of the packaged product (the relative humidity of the predetermined control)
2.the water content of the product itself
3. The properties of the packaging materials used in the product (especially moisture permeability)
4.the level of sealing of the product packaging
5.The temperature and humidity of the environment when the product is packaged, the shelf life of the product, the environment and climatic conditions for product transportation and storage, etc.
6.the absorbency of the desiccant

Biologics packaging - COP vials

With the continuous development of biopharmaceutical technology,the COP vials are used more and more widely.

COP vials are made from a cyclic olefin polymer (COP); polymers are considered to be more stable materials than glass compared to glass. Compared with most glass bottles, COP has no protein adsorption, which can guarantee the content of active ingredients in medicines. Due to the use of polymer material properties, it has a high-end positioning in the industry compared to most vials. It is especially suitable for complex molecules and sensitive drugs that require high stability.

What are the main factors in the storage management of veterinary medicine?

The quality of veterinary medicines includes the intrinsic quality, appearance quality and packaging quality of the drugs. The appearance quality of a drug refers to the physical and biological properties of the drug, such as color, odor, crystal or insoluble matter, morphology, solubility, weathering, deliquescence, mildew, insects and so on.
1.visual inspection: 1 inspection of packaging, containers and labels; 2 inspection of raw materials; 3 inspection of various preparations.
2. Factors affecting the deterioration of drugs:

• Air: The oxygen in the air can cause many of the reducing agents to oxidize and produce toxicity, such as oil rancidity; carbon dioxide in the air makes the sulfa drug carbonate.
• Light: Ultraviolet rays can cause many drugs to undergo chemical reactions such as discoloration, oxidation, reduction and decomposition. For example, silver nitrate and mercury are photosynthetically reduced to precipitate dark brown toxic silver and mercury.
• Temperature: The increase of temperature can accelerate the volatility of the drug, and more importantly, it can promote chemical reactions such as oxidation and decomposition to accelerate the deterioration of the drug. For example, serum, vaccine and organ preparations are easy to be stored at room temperature, and need to be refrigerated at low temperature; The increase in temperature also tends to soften the ointment and capsules, and accelerate the volatilization of volatile drugs. However, if the temperature is too low, some drugs or preparations will be used to precipitate. For example, formaldehyde will form a polymeric precipitate under 9 ° C to precipitate a white precipitate; low temperature will also cause the liquid drug to freeze, causing the container to rupture.
• Humidity: The water vapor content in the air is called humidity. Humidity is the most variable part of the air and fluctuates with the region, season and temperature. Humidity has a great impact on drug storage. If the humidity is too large, the drug can absorb moisture and deliquesce, dilute, deform, and mold; the humidity is too small, and the drug containing crystal water is easily weathered (loss of crystal water).
• Microorganisms and insects: When drugs are exposed to the air, they are metabolized by microorganisms and insects, causing deterioration, fermentation, mildew and insects.
• Time: Any medicine that has been stored for too long will deteriorate, but different medicines will change at different speeds. Antibiotics, biological agents, organ preparations and certain chemicals are all valid and must be used within the validity period.