how to choose the desiccant for pharmaceutical packaging

 

caps with silica for effervescent tablet tubes

How to choose the desiccant like silica gel or molecular sieve for pharmaceutical packaging.

No matter you choose silica gel or molecular sieve,the first step is that confirm the dosage of the desiccant which you will use in the effervescent tube. You need confirm the size of effervescent tube,then according to the size,confirm the dosage of the desiccant.In generally,the dosage of effervescent tube is 2.1g and 3.9g. 

Then you need research your target market,your target market whether permit use molecular sieve,because some countries don't permit use molecular sieve, the temperature of storing environment can influence the moisture absorption ability of silica gel and molecular sieve.The most suitable temperature of silica gel is 20~32°C and 60~90°C.

effervescent tablet tubes densitometry

The density of pharmaceutical packaging materials is generally determined by the impregnation method, that is, the density is determined according to buoyancy. Impregnation law means that the buoyancy force received by the sample in the impregnation solution at a specified temperature is equal to the product of the volume of the sample displaced by the impregnation solution and the density of the impregnation solution. The buoyancy can be obtained by measuring the mass of the sample and the mass of the sample in the macerate. This method is applicable to the determination of the density of plastic containers (materials) other than foam plastics, and can be used for qualitative identification of materials.

effervescent packaging

The instrument

Scale with accuracy of 0.1mg, attached to densitometer (minimum dividing value of thermometer is 0.5°C)

Preparation and determination of test products

The test product should be placed in an environment of 23°C±2°C with relative humidity of 50%±5% for more than 4 hours, and then tested under this condition. The test product should be a task other than powder and a material without pores. The surface of the test product should be smooth, flat, no sag, clean, no crack, no air bubble and other defects. The size is suitable, and the quality of the sample should not exceed 2g.

New boiling water or other suitable liquid should be used for the macerate. The liquid that does not act with the sample can be added with lubricant if necessary, but less than 0.1% of the total volume of macerate should be used to remove small bubbles. During the test, when the test product comes into contact with the liquid, it shall have no effect on the test product. The density of macerate is generally light rain density; Water can be used when the material density is greater than 1, and anhydrous ethanol can be used when the material density is less than 1.

Vitamin C effervescent tablets and packaging form

Vitamin C effervescent tablets as the name implies refers to the vitamin C through medical technology processing into effervescent tablets. Different from ordinary tablets, effervescent tablets make use of organic acid and basic carbonic acid (hydrogen) salt reaction as vesicle disintegrating agent, put into water, immediate effervescent reaction occurs, generate and release a large amount of carbon dioxide gas, like boiling, hence the name effervescent tablets.

Vitamin C for antibodies and collagen formation, tissue repair (including some REDOX function, metabolism of phenylalanine, tyrosine, folic acid, iron, carbohydrate, fat, protein synthesis, maintain immune function, hydroxyl serotonin, full blood vessels, promote the heme iron absorption and so on necessary, at the same time also has antioxidant, vitamin C fight free radicals, inhibit the formation of tyrosinase, so as to achieve whitening, pale spot effect.

vitamin c tablets packaging

Compared with ordinary, effervescent tablet agent is put into water in vitro and dissolves rapidly, releasing a large amount of carbon dioxide gas and dissolving into liquid. Generally, the disintegrating time is 1-5min. The disintegration time is 15~60min. Effervescent tablets are more easily absorbed by the body. Effervescent tablets were disintegrated and dissolved in vitro. After oral administration, the liquid was distributed in a large area of the gastrointestinal tract and absorbed into the blood through the gastrointestinal tract for about 10-30min, which reduced the local irritation of the drug in the gastrointestinal tract, thus reducing the side effects and achieving rapid and efficient effects. After oral administration, common tablets disintegrate in the stomach, slowly dissolve the drugs, and absorb them into the blood through the stomach and intestines. It takes 2~3h to reach the effective blood drug concentration, and the effect is slow.

effervescent tablet tubes

Vitamin C effervescent tablet is more strict to packing requirement, especially moisture-proof and sealing are more important. Effervescent tablet is affected by damp meeting medicine can produce metamorphism, cause to lose or reduce effect of medicine. So vitamin C effervescent piece pack chooses to contain moistureproof commonly, sealing good packing form.

How to open the cap of the effervescent tablet tube

Effervescent tablet tube with desiccant and stopper is a wonderful packaging for some food, medicine and test strip. Dry environment can keep food, medicine and test strip healthy with their need.

The tubes with desiccant and stopper are made of tubes, desiccant, stoppers and even spiral. And then how to open tubes with desiccant and stopper?

First, when there are tablets in the tubes, it is sealing, looking for a notch on the cap.

Second, just put your thuumb on the notch of cap.

Third, push up the cap.

Fourth, the ring will fall off, the cap is open.

The way of opening tubes with desiccant and stopper is easy and convenient, but it is hard for children to open, because it need large strength to separate the cap and ring . So it is safe for children.

Effervescent Tube with Spiral Desiccant Closure

The spiral desiccant closures or stoppers for our effervescent tablet tubes provide maximum protection while enhancing the shelf life of your product. Our spiral desiccant closures come with an inbuilt tamper evident ring which can protect the integrity of your product while the spiral design of spiral desiccant closure helps in keeping the product in place during transportation.

moisture proof tamper closure

As the industry level of misconduct and OTC drugs introduced the New Deal, industry demand for pharmaceutical packaging will be toward a more secure, more convenient, faster and more environmentally friendly direction.At present, the majority of drug packaging, quality generally unstable, with function of moisture-proof and deoxidizer function of medicinal plastic moisture proof cover less plastic bottles, nearly 7 compounds packaging are not up to international standards. Most domestic pharmaceutical packaging enterprise does not pay attention to technology and new materials research and development, still less investment in technology. Overall packaging materials of low value-added products, pharmaceutical packaging in the international market accounted for 30% of the value of the drug, compared with only 10% in China, far behind the international market.

effervescent packaging

As consumers purchasing trend gradually increase, medical market is more and more big, the pharmaceutical packaging market by the glass to plastic products, plastic pharmaceutical packaging more attention and concern.Pharmaceutical companies appearance of packaging, packaging design and packaging, quality promotes gradually, OTC drugs is more outstanding.

According to this situation, shijiazhuang Xinfuda Medical Packaging co., LTD., a new developed with moistureproof cover oral solid pharmaceutical plastic bottles, small drug storehouse of moistureproof cover deoxidizer, desiccant can be canned.More security and prevent children open the auxiliary function, good sealing, in line with the national drug packaging materials and containers registration certificate, without aluminum foil sealing.